Currently, one of the most discussed topic is the problem of drug abuse in adolescents. The number of requests for investigation of drugs by doctors, as well as parents increases over the years and is growing in proportion to the number of positive findings. In addition to „traditional“ drugs, the emergence of new psychoactive substances has been recorded in eastern Slovakia. The aim of this work is to provide information on the presence of two synthetic substances desoxypipradrol (2-diphenylmethylpiperidine, 2-DPMP) and α-pyrrolidinovalerophenone (alpha-PVP) in the eastern region of Slovakia and statistically evaluate the results of our analysis for the period 2012-2014, and compare data on the use of these drugs with „traditional“ drugs such as marijuana, amphetamines, opiates and cocaine. Samples were collected from psychiatric clinics and the Center for Treatment of Drug Addiction (CTDD) in Košice. Patient samples were sent to our laboratory under routine toxicological testing for the presence of drugs and other abused drugs. The presence of new psychoactive substances was determined using a highly sensitive chromatography techniques – GCMS and LCMSMS. These methods were selected as reliable for the identification of the original form of the drugs and their metabolites. More than 80 % chromatographic analyses (of total 4996) were performed for the purpose of detection of illicit substances over the years 2012 to 2014. Analysis has shown that the number one drug in eastern Slovakia is marijuana. A new phenomenon among new drugs are stimulants, the sale of which is often masked. Since the beginning of 2012 the incidence of two psychostimulants, 2-DPMP and alpha-PVP has been observed.

Key words: desoxypipradrol – α-pyrrolidinovalerophenone – designer drugs – traditional drugs – toxicological analysis – chromatographic techniques